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Synthesis, Radiosynthesis, and Biological Evaluation of New Proteasome Inhibitors in a Tumor Targeting Approach

✍ Scribed by Vivier, Magali; Rapp, Maryse; Papon, Janine; Labarre, Pierre; Galmier, Marie-Josephe; Sauzière, Jacques; Madelmont, Jean-Claude


Book ID
125935595
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
101 KB
Volume
51
Category
Article
ISSN
0022-2623

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Phosphorylation of serine, threonine, and tyrosine controls fundamental mammalian cell events and is achieved by kinases which, in turn, are in dynamic relationship with phosphatases. Few selective inhibitors of protein tyrosine and dual specificity phosphatases are readily available. Based on SAR s