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Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues

✍ Scribed by Giordano Lesma, Severo Salvadori, Francesco Airaghi, Engin Bojnik…

Book ID
120750561
Publisher
Springer
Year
2012
Tongue
English
Weight
620 KB
Volume
17
Category
Article
ISSN
1381-1991

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✍ Zhi-Hao Shi; Yun-Yang Wei; Chuan-Jin Wang; Li Yu 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB

## Abstract Endomorphin‐2 (**1**; H‐Tyr‐Pro‐Phe‐Phe‐NH~2~; EM2) and its novel cyclic asparagine (__cyclo__Asn) analogues, H‐Tyr‐__c__Asn(CHPh)‐Phe‐Phe‐NH~2~ (**2**) and H‐Tyr‐__c__Asn(CHMe~2~)‐Phe‐Phe‐NH~2~ (**3**), were synthesized __via__ liquid‐phase synthesis. The structures of the products and