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Synthesis on soluble polymers: new reactions and the construction of small molecules

✍ Scribed by Dennis J Gravert; Kim D Janda

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
712 KB
Volume
1
Category
Article
ISSN
1367-5931

No coin nor oath required. For personal study only.

✦ Synopsis

To avoid the heterogeneous reaction conditions of solid-phase chemistry, liquid-phase synthesis provides homogeneity through the use of soluble polymer supports that can be selectively precipitated and filtered to achieve product purification. Peptides, oligonucleotides, and oligosaccharides have been synthesized by this method. Furthermore, combinatorial libraries of small molecules have been produced by liquid-phase synthesis to aid in the search for new pharmaceutical agents including compounds active against HIV. Soluble polymeric reagents have also been developed for greater ease and efficiency in organic synthesis.

πŸ“œ SIMILAR VOLUMES

Synthesis utilizing insoluble polymers:
Synthesis utilizing insoluble polymers: new reactions and small molecules
✍ Anthony D Baxter πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 641 KB

It can be argued that solid-phase organic chemistry is the preferred method of preparing screening libraries for lead compound discovery and lead optimization within the pharmaceutical industry. Solid-phase peptide chemistry is the most reliable and general of the synthetic methods available today;