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Synthesis, oligonucleotide incorporation and base pair stability of 7-methyl-8-oxo-2?-deoxyguanosine

✍ Scribed by Hamm, Michelle L.; Billig, Kelly


Book ID
119943756
Publisher
Royal Society of Chemistry
Year
2006
Tongue
English
Weight
124 KB
Volume
4
Category
Article
ISSN
1477-0520

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8-Azaadenosine and Its 2β€²-Deoxyribonucle
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The synthesis of 8-azaadenosine (la; z8A) has been performed by SnCI,-catalyzed glycosylation of X-azaadeninc (4) with I ,2,3.5-tetra-O-acetyl-/7-~-rihofuranose (5). followed by the separation of the regioisomers 6 and 7 and subsequent deacetylation. The ribonucleoside la as well as its 2.'-deoxy de