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Synthesis ofVinca alkaloids and related compounds, LIV. Synthesis of (±)-16-deethyl-vincamines, (Deethyl)-16-deethyl-apovincamines, and their 10-bromo derivatives

✍ Scribed by Sápi, János ;Szabó, Lajos ;Thurner, Angelika ;Baitz-Gács, Eszter ;Tamás, József ;Kalaus, György ;Szántay, Csaba

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 417 KB
Volume: 1990
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.1990199001205

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✦ Synopsis

Abstract

A versatile method for introducing a functionalized side chain into enamines 9a and 11a is described. This procedure provides an easy access to 16‐deethyl‐vincamines 16, 17 and 16‐deethyl‐apovincamines 18–21.

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Synthesis of vinca alkaloids and related compounds, 73. Synthesis and ring transformations of deethylaspidospermane derivatives. Synthesis of (±)-20-deethyl-3-oxotabersonine

✍ Kalaus, György ;Juhász, Imre ;Greiner, István ;Kajtár-Peredy, Mária ;Brlik, Jáno 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 823 KB

## Abstract The reaction of the key compound 14 with methyl 4‐formyl‐butanoate (9) or with 5‐benzoyloxypentanal (13) gave the D‐__seco__‐aspidospermane derivatives 17 and 18, respectively. Compound 17 was indirectly and 18 was directly converted to (±)‐20‐deethylvincadifformine (7) and (±)‐20‐deeth