Stereoselective synthesis of stable isot
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Siegfried N. Lodwig; Clifford J. Unkefer
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Article
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1996
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John Wiley and Sons
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French
⚖ 475 KB
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Using 1 -chloro-l-[~~N]nitrosocyclohexane, we have prepared five L-[a-'SN]arnino acids. The stereoselective electophillic hydroxyamination of (S)-acylbornane-l0,2-suftams, followed by ZnO/H+ reduction, and alkaline cleavage of the chiral auxiliary, gave the amino acids in 97.2-99.5 % e.e. By starti