Synthesis of ω-(Hetero)arylalkynylated α-Amino Acid by Sonogashira-Type Reactions in Aqueous Media
✍ Scribed by Brea, Roberto J.; López-Deber, M. Pilar; Castedo, Luis; Granja, Juan R.
- Book ID
- 111888673
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 102 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0022-3263
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Alkyl radical addition to glyoxylic oxime ether and hydrazone in aqueous media was studied using zinc dust as a radical initiator. The zinc-mediated radical reaction of the hydrazone bearing a chiral camphorsultam provided the corresponding alkylated products with good diastereoselectivities, which