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Synthesis of γ-carboxyglutamic acid-containing peptides by the Boc strategy

✍ Scribed by NISHIUCHI, YUJI ;NAKAO, MASAYUKI ;NAKATA, MAKOTO ;KIMURA, TERUTOSHI ;SAKAKIBARA, SHUMPEI


Book ID
115099503
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
475 KB
Volume
42
Category
Article
ISSN
0367-8377

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✍ Masayuki Nakao; Yuji Nishiuchi; Makoto Nakata; Takushi X. Watanabe; Terutoshi Ki 📂 Article 📅 1995 🏛 Springer Netherlands 🌐 English ⚖ 588 KB

Conotoxin GS, a y-carboxyglutamic acid(Gla)-containing neurotoxic peptide composed of 34 amino acid residues with'one Gla residue and three intramolecular disulfide bonds, was synthesized in solution by the Boc strategy, using the cyclohexyl group to protect the y,y-dicarboxyl functional side chain