A lacile slereoselcctive melhod Ior the synthesis of y-substituted, y-mnino acids from of amino acids was developed. The key step of the procedurc is complete reduction of Ihe keto functionality of ot-~unino acyl Meldruln's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid
Synthesis of γ-amino acid analogues from natural α-amino acids by a radical pathway
✍ Scribed by M. C. Corvo; M. M. A. Pereira
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 99 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0939-4451
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A general, stereospecific, synthesis of S,Y-unsaturated a-amino acids using the S-anion derived from aspartic acid is described . S,Y-Unsaturated amino acids have been found to be reversible or irreversible inhibitors of a number of enzymes,' and this has prompted a number of racemic syntheses of th
Facile Stereoselective Synthesis of γ-Substituted γ-Amino Acids from the Corresponding α-Amino Acids. -The mild and short procedure presented is compatible with common side-chain protecting groups, sensitive functionalities and preserves the chirality of the starting α-amino acid.