Synthesis of β-Cyclodextrin Containing Copolymer via “Click” Chemistry and Its Self-Assembly in the Presence of Guest Compounds
✍ Scribed by Jianxiang Zhang; Kristin Ellsworth; Peter X. Ma
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 612 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1022-1336
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✦ Synopsis
Abstract
We report the synthesis of a hydrophilic copolymer with one polyethylene glycol (PEG) block and one β‐cyclodextrin (β‐CD) containing block by a “click” reaction between azido‐substituted β‐CD and propargyl flanking copolymer. ^1^H NMR study suggested a highly efficient conjugation of β‐CD units by this approach. The obtained copolymer was used as a host macromolecule to construct assemblies in the presence of hydrophobic guests. For assemblies containing a hydrophobic polymer, their size can be simply adjusted by simply changing the content of hydrophobic component. By serving as a guest molecule, hydrophobic drugs can also be loaded accompanying the formation of nanoparticles, and the drug payload is releasable. Therefore, the copolymer synthesized herein can be employed as a carrier for drug delivery.