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Synthesis of β-azomycin nucleosides: 1-(β-d-2-iodo-2-deoxyarabinofuranosyl)-2-nitroimidazole (β-2-IAZA), a novel marker of tissue hypoxia

✍ Scribed by Piyush Kumar; Leonard I. Wiebe; Davood Beiki; Kazue Ohkura; Koh-Ichi Seki


Book ID
104251263
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
67 KB
Volume
43
Category
Article
ISSN
0040-4039

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The synthesis of t h e title canpound (7) is described. [2-14C] cytosine (I) is treated with an aqueous mixture of sodium bisulfite and sodium sulfate at 8OoC for 30 rnin. The resulting solid is then treated with aqueous sodiun hydroxide and passed through a cation exchange colunn, producing [ Z-14C