✦ LIBER ✦
Synthesis of β-alanyl-arginyl-glycyl-phenylalanyl-phenyl-alanyl-typosine amide labelled with tritium or carbon-14
✍ Scribed by Nobuyoshi Hayashi; Takeo Kawakami; Kazuo Shinozaki; Mitsuhiro Wakimasu; Masahiko Fujino
- Book ID
- 102370879
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 336 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The synthesis of β‐Ala‐Arg‐Gly‐Phe‐Phe‐Tyr‐NH~2~ labelled with tritium on the tyrosine residue or with carbon‐14 on the arginine residue is described. The tritium labelled compound VII was prepared in 49% radiochemical yield from L‐[3, 5‐^3^H] tyrosine and benzyloxycarbonyl‐β‐alanyl‐nitro‐arginyl‐glycyl‐phenylalanyl‐phenylalanine. The carbon‐14 labelled compound XVI was synthesized in 17% radiochemical yield from L‐[U‐^14^C]arginine and glycyl‐phenylalanyl‐phenylalanyl‐tyrosine amide.