Synthesis of αβ-Unsaturated Trifluoromethyl Ketones from 4-Dimethylamino-1,1,1-trifluorobut-3-ene-2-one by Addition of Grignard Reagents
✍ Scribed by Rebecca J. Andrew; John M. Mellor
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 110 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCI catalysis. Moderate to good yields (43-68%) of trifluoromethyl carbinols are obtained with symmetric and unsymmetri