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Synthesis of α,α-Difluoroethyl Aryl and Heteroaryl Ethers

✍ Scribed by Yang, Eddie; Reese, Matthew R.; Humphrey, John M.


Book ID
115534710
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
338 KB
Volume
14
Category
Article
ISSN
1523-7060

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Asymmetric synthesis of α,α-diaryl and α
✍ Anthony W Shaw; S.Jane deSolms 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 105 KB

Organometallic addition to tert-butanesufinyl ketimines derived from diaryl and aryl-heteroaryl ketones provided the corresponding a,a-diaryl and a-aryl-a-heteroaryl alkylamines in good yield with high diastereoselectivity. In many cases, imine facial selectivity is reversed on changing the organome