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Synthesis of α-trifluoromethyl α-amino acids with aromatic, heteroaromatic and ferrocenyl subunits in the side chain

✍ Scribed by K. Burger; L. Hennig; P. Tsouker; J. Spengler; F. Albericio; B. Koksch


Book ID
111707355
Publisher
Springer
Year
2006
Tongue
English
Weight
198 KB
Volume
31
Category
Article
ISSN
0939-4451

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Synthesis of N-Fmoc-α-amino acids carryi
✍ Paola Ciapetti; Francesco Soccolini; Maurizio Taddei 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 766 KB

Four new N-Fmoc cc-amino acids carrying a nucleobase in the side chain were prepared starting from L-glutamic acid. N-Boc-glutamic acid ct benzyl ester underwent a radical decarboxylation in the presence of CBrCl3 to give the corresponding 2-amino-4-bromobutanoic acid derivative. The four nucleobase