Synthesis of α-Forkoxystybene and α-Halogenated Acetoxystykenes by Addition of Carboxylic Acids to Phsnylacetylene
✍ Scribed by Monthéard, Jean-Pierre; Camps, Marcel; Benzaid, Armed
- Book ID
- 126954151
- Publisher
- Taylor and Francis Group
- Year
- 1983
- Tongue
- English
- Weight
- 153 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0039-7911
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📜 SIMILAR VOLUMES
The synthesis of tertiary carbinamines was achieved by the double nucleophilic addition of Grignard reagents to cyanohydrins. Titanium isopropoxide was found to promote the process. In a typical example, the rapid conversion of a carbinamine to the coresponding o~.o~-disubstitutedct-aminoacid was a
The sequential addition of two different nucleophiles to a tartaric acid-derived nitrile produced carbinamines. The adducts from chelation-controlled addition which are obtained in high diastereoselectivities and yields, were easily converted to ct,ct-disubstituted-t~-amino acids.