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Synthesis of α-Diaminomethylenebutyrolactams by the Reaction of α-Cyanobutyrolactams with N-Trimethylsilylamines.

✍ Scribed by Fumi Okabe; Syouhei Nakamura; Kenji Yamagata


Publisher
John Wiley and Sons
Year
2007
Weight
19 KB
Volume
38
Category
Article
ISSN
0931-7597

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Synthesis of α-diaminomethylenebutyrolac
✍ Fumi Okabe; Syouhei Nakamura; Kenji Yamagata 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 261 KB

## Abstract magnified image Successive treatment of α‐cyanobutyrolactams **1** with __N__‐trimethylsilylamines and water gave the corresponding α‐diaminomethylenebutyrolacatms **2** in good yields. In the NOESY spectra of **2**, the __E__ isomer, the NOE observed between β‐CH~2~ (butyrolactam) and