Synthesis of α-Aryl-Substituted and Conformationally Restricted Fosmidomycin Analogues as Promising Antimalarials
✍ Scribed by Timothy Haemers; Jochen Wiesner; Roger Busson; Hassan Jomaa; Serge Van Calenbergh
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 158 KB
- Volume
- 2006
- Category
- Article
- ISSN
- 1434-193X
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Five synthetic, conformationally restricted ␣-ketoglutarate analogues were tested as substrates of a variety of dehydrogenases and aminotransferases. The compounds were found not to be detectable substrates of glutamate dehydrogenase, L-leucine dehydrogenase, L-phenylalanine dehydrogenase, lactate d