Synthesis of α- and β-amino ketone analogs of amino acids as antibacterial agents

✍ Scribed by Shu-Sing Cheng; Sigurdur Jonsson; Fred T. Semeniuk

• Publisher: John Wiley and Sons
• Year: 1962
• Tongue: English
• Weight: 461 KB
• Volume: 51
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600510205

✦ Synopsis

to a change in transference numbers of the potassium and chloride ions in the solution being measured. They demonstrated this effect by observing a potential drop across two calomel electrodes, one immersed in the suspension, the other in the supernatant liquid.

T o eliminate this error, an equilibrium mixture of amphetamine sulfate and sodium stearate was centrifuged to remove the suspended material. The pH was again determined and found to be 8.6, which is in reasonable agreement with the calculated value, 8.49, from Eq. 4.

From these results it is proposed that Eq. 3 is descriptive of the system, and that the role of basic lubricants is the removal of hydrogen ion to promote the base-catalyzed browning of lactose. These findings coupled with later tests using inorganic alkalies indicate that the reaction is a general basecatalyzed reaction and not limited to amine bases.

It should be noted that the pH values shown in Fig. 1 are those of suspensions and contain the errors discussed above.