✦ LIBER ✦

Synthesis of α-[5-(5-amino-1,3,4-thiadiazol-2-yl)-2-imidazolylthio]acetic acids

✍ Scribed by Farzin Hadizadeh; Rahil Vosooghi

Publisher: Journal of Heterocyclic Chemistry
Year: 2008
Tongue: English
Weight: 268 KB
Volume: 45
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570450537

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✦ Synopsis

Abstract

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The paper describes synthesis and antituberculosis activity of α‐[5‐(5‐amino‐1,3,4‐thiadiazol‐2‐yl)‐imidazol‐2‐ylthio]acetic acids (5a,b). The compounds were tested against Mycobacterium tuberculosis strain H37Rv in comparison to rifampicin. Compounds exhibited low activity (MIC ≤ 6.25 μg/ml, % inhibition ≥ 24).

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