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Synthesis of water-soluble prodrugs of the cytotoxic agent Combretastatin A4

โœ Scribed by Simon B Bedford; Charmaine P Quarterman; Daniel L Rathbone; John A Slack; Roger J Griffin; Malcolm FG Stevens

Book ID
108038946
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
203 KB
Volume
6
Category
Article
ISSN
0960-894X

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โœ Magali Lorion; Vangelis Agouridas; Axel Couture; Eric Deniau; Pierre Grandclaudo ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 460 KB

A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.