Synthesis of water-soluble biologically active phenol (or catechol) containing copolymers of N-vinyl-2-pyrrolidone

✍ Scribed by Michael V. Solovskij; Victor M. Denisov; Eugenij F. Panarin; Natalija A. Petukhova; Alla V. Purkina

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 590 KB
• Volume: 197
• Category: Article
• ISSN: 1022-1352
• DOI: 10.1002/macp.1996.021970620

✦ Synopsis

Abstract

Water‐soluble N‐vinyl‐2‐pyrrolidone (VP) copolymers containing phenol (or catechol) groups in the side chains were synthesized by reactions of copolymers of VP and crotonic acid (CA) with p‐aminophenol and by reaction of p‐nitrophenyl ester groups containing VP‐CA copolymers with dopamine. It was established that phenol (or catechol) containing multiunit VP copolymers (which were characterized by GPC, viscometry, UV, IR and ^1^H NMR spectroscopy) exhibit immunostimulating activity. In addition, the phenol‐containing copolymers exhibit antitumor activity. The VP‐CA‐p‐crotonoylaminophenol terpolymer can be used as a macromolecular carrier in the synthesis of a carcinogen‐polymer antigen: a polymeric azo derivative of ß‐naphthylamine.