Synthesis of Water Soluble, Biodegradable, and Electroactive Polysaccharide Crosslinker with Aldehyde and Carboxylic Groups for Biomedical Applications
✍ Scribed by Qian Wang; Wen He; Junqi Huang; Siwei Liu; Guifu Wu; Wei Teng; Qinmei Wang; Yugang Dong
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 633 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
We report the synthesis and characterization of a polysaccharide crosslinker of tetraaniline grafting oxidized sodium alginate with large aldehyde and carboxylic groups. We demonstrate that this copolymer has the following properties: it is water soluble under any pH, biodegradable, electroactive, and noncytotoxic; it can self‐assemble into nanoparticles with large active functional groups on the outer surface; it can crosslink materials with amino and aminoderivative groups like gelatin to form hydrogels, and thus the electroactivity is readily introduced to the materials. This copolymer has potential applications in biomedical fields such as tissue engineering, drug delivery, and nerve probes where electroactivity is required. magnified image