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Synthesis of vitamin D3esters

โœ Scribed by R. I. Yakhimovich; A. N. Esaulenko; L. M. Yusupova; A. V. Turov; V. K. Bauman; M. Yu. Valinietse


Book ID
112407583
Publisher
Springer
Year
1991
Tongue
English
Weight
335 KB
Volume
25
Category
Article
ISSN
0091-150X

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Recently much attention has focused on inducing the hydroxyl group at C-1 and C-25 positions of 1 to obtain the active compound (2, 3, and 4). ## A. From Cholesterol Barton et a1.6 reported in 1973 the convenient synthesis of 1-OH-D3 (3) from la,2a-epoxycholesta-4,6-dien-3-one (8) (obtained from

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In existing total syntheses 192 of vitamin D 3 the conjugated triene system is not constructed directly; instead, an isomeric triene, either 5-trans-vitamin D31b or precalcifero13,2 is first elaborated, and is then transformed into the vitamin itself by photochemical or thermal isomerisation. Vitam