Synthesis of vinyl sulfides via hydrothiolation of alkynes using Al2O3/KF under solvent-free conditions

✍ Scribed by Márcio S. Silva; Renata G. Lara; Júnior M. Marczewski; Raquel G. Jacob; Eder J. Lenardão; Gelson Perin

• Book ID: 104095019
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 129 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.01.093

✦ Synopsis

We present here a clean, solvent-free hydrothiolation of alkynes using solid supported catalyst (Al 2 O 3 /KF). This efficient and improved method selectively furnishes the corresponding anti-Markovnikov vinyl sulfides in good to excellent yields. The method is applicable for aliphatic and aromatic thiols and the catalytic system can be re-used up to two times without previous treatment and with comparable activity.