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Synthesis of Vinca Alkaloids and Related Compounds. 100. Stereoselective Oxidation Reactions of Compounds with the Aspidospermane and Quebrachamine Ring System. First Synthesis of Some Alkaloids Containing the Epoxy Ring 1a

✍ Scribed by Éles, János; Kalaus, György; Greiner, István; Kajtár-Peredy, Mária; Szabó, Pál; Keserû, György Miklós; Szabó, Lajos; Szántay, Csaba


Book ID
121864758
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
152 KB
Volume
67
Category
Article
ISSN
0022-3263

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Synthesis of vinca alakaloids and realat
✍ János Éles; György Kalaus; Lajos SzabÓ; Albert LÉvai; IstvÁn Greiner; MÁria Kajt 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 62 KB

## Abstract The oxidation of (‐)‐tabersonine (**1**) with dimethyldioxirane (DMD) in neutral and acidic medium gave 16‐hydroxytabersonine‐__N__‐oxide (**3**) and the didehydrovincamine isomers **4** and **5**, respectively. (+)‐14,15‐Didehydro‐quebrachamine (**7**) furnished the hydroxyindolenine *