Synthesis of Versatile Nonsymmetric Amine- and Boron-Functionalized Tröger's Base Derivatives, Including a Tröger's Base Amino Acid
✍ Scribed by Whiting, Amanda L.; Dubicki, Krystyn I.; Hof, Fraser
- Book ID
- 121198861
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 521 KB
- Volume
- 2013
- Category
- Article
- ISSN
- 1434-193X
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## Abstract Four novel molecular tweezers, **6**–**9**, have been synthesized having, for the first time, three fused __Tröger__'s bases. The compounds differ in the relative configuration of the three fused methylene bridges and have been unambiguously characterized by NMR.
Fourteen amino heterocycles were allowed to react in the different experimental conditions of formation of Tr0ger's bases. Amino-azoles and -benzazoles yielded the corresponding Tr0ger's bases while amino-azines and -benzazines failed to react. The exception was 6-aminoquinoline which yielded the co