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Synthesis of two Unique Compounds, a Ceramide and a Cerebroside, Occurring in Human Stratum Corneum

✍ Scribed by Silvia Müller; Richard R. Schmidt

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 110 KB
Volume: 342
Category: Article
ISSN: 1615-4150
DOI: 10.1002/1521-3897(200010)342:8<779::aid-prac779>3.0.co;2-8

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✦ Synopsis

Extra-and intracellular ceramides of the epidermis seem to play important roles [1][2][3]. The permeability barrier of the skin, which prevents transcutaneous water loss and penetration of harmful drugs from the environment, is localized in the horny layer (stratum corneum) of the epidermis [1,2]. The stratum corneum lipids are essentially responsible for the proper functioning of the epidermal barrier. Mostly ceramides, cholesterol and free fatty acids are found within the stratum corneum

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✍ Siliva Müller; Richard R. Schmidt 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 German ⚖ 984 KB

The sphingolipids la, b and 2a, b, which play important roles in epidermal barrier function, were synthesized by N-acylation of C,,-sphingosine 3 and I-0-glucosylated C,,-sphingosine 6, respectively, with w-acyloxy-substituted fatty acids 4 and 5 (Scheme 1 ) . These fatty acids were obtained from w-