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Synthesis of two novel oxocyclam-binding technetium complexes containing an analogue of cocaine

✍ Scribed by F. Turpin; F. Masri; F. Riché; E. Berthommier; P. Emond; M. Vidal; P. Auzeloux; C. Loc'h; N. Neuquelman; L. Mauclaire

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
172 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

In order to visualize and quantify dopamine transporters, the synthesis of two novel ligands labelled with technetium‐99 m (^99m^Tc) has been investigated. A multi‐step synthesis afforded two target ligands with a tropane skeleton and a macrocyclic complexing moiety. The choice and the position of substituents are in adequation with dopamine transporter structure. The radiolabelling of these ligands with ^99m^Tc has been studied and the results make them good candidates for SPECT imaging. Copyright © 2002 John Wiley & Sons, Ltd.

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