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Synthesis of two new alkyne-bearing linkers used for the preparation of siRNA for labeling by click chemistry with fluorine-18

✍ Scribed by Jessica Flagothier; Geoffroy Kaisin; Frederic Mercier; David Thonon; Nathalie Teller; Johan Wouters; André Luxen


Book ID
116243242
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
444 KB
Volume
70
Category
Article
ISSN
0969-8043

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[18F]FPyKYNE, a fluoropyridine-based alk
✍ Bertrand Kuhnast; Françoise Hinnen; Bertrand Tavitian; Frédéric Dollé 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 183 KB

## Abstract FPyKYNE (2‐fluoro‐3‐pent‐4‐yn‐1‐yloxypyridine) is a novel fluoropyridine‐based structure, designed for the fluorine‐18 labelling of macromolecules using copper‐catalysed Huisgen 1,3‐dipolar cycloaddition (click chemistry). FPyKYNE (non‐labelled as reference), as well as the 2‐bromo, 2‐n