Synthesis of Two Metabolites of the Anti
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Barbara Wendt; Huy Riemβ
Ha; Manfred Hesse
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Article
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2002
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John Wiley and Sons
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German
β 148 KB
The metabolism of the potent antiarrythmic drug amiodarone (AMI; 1) has yet not been fully investigated. Recently, in vitro experiments revealed that in rabbit-liver microsomes, AMI (1) and its main metabolite MDEA (2) were biotransformed to the hydroxylated derivatives 3'-OH-AMI (3) and 3'-OH-MDEA