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Synthesis of Two Metabolites (Ib) and (Ic) of the Antiarrythmicum Amiodarone (Ia).

✍ Scribed by Barbara Wendt; Huy Riem Ha; Manfred Hesse


Publisher
John Wiley and Sons
Year
2003
Weight
67 KB
Volume
34
Category
Article
ISSN
0931-7597

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The metabolism of the potent antiarrythmic drug amiodarone (AMI; 1) has yet not been fully investigated. Recently, in vitro experiments revealed that in rabbit-liver microsomes, AMI (1) and its main metabolite MDEA (2) were biotransformed to the hydroxylated derivatives 3'-OH-AMI (3) and 3'-OH-MDEA

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