Synthesis of tritium-labeled DL-γ-carbox
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Yoshinori Ishikawa; Roy E. Wuthier
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Article
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1984
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John Wiley and Sons
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French
⚖ 407 KB
By condensing diethyl ethoxymethylenemalonate with diethyl acetamidomalonate, 5-hydroxy-2,4-dicarbethoxypyrrole was prepared. Hydrogenation over Pt-C to 5-oxo-2,4-dicarbethoxypyrrolidine, followed by alkaline hydrolysis gave y-carboxyglutamate. Mild alkaline hydrolysis yielded 5-oxo-2,4-pyrrolidine