Synthesis of Tumor-Inhibiting Complex Salts Containing the Anion trans-Tetrachlorobis(indazole)ruthenate(III) and Crystal Structure of the Tetraphenylphosphonium Salt
✍ Scribed by Wolfgang Peti; Thomas Pieper; Martina Sommer; Bernhard K. Keppler; Gerald Giester
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 234 KB
- Volume
- 1999
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
Indazolium
trans-tetrachlorobis(indazole)ruthenate(III) n-butylammonium, n-octylammonium, and tetraphenylphosphonium salts, all of which showed improved solubility exhibits excellent results against different tumor models in vitro and in vivo. To improve the water solubility necessary in organic solvents. The X-ray crystal structure of the latter could be solved, proving the trans configuration of the for the introduction of this tumor-inhibiting compound into clinical trials, we synthesized the corresponding sodium salt complex anion. In spite of the paramagnetic Ru III center an assignement of the coordinated indazole protons could be in a two-step ion exchange via the tetramethylammonium salt. The sodium salt shows a 35-fold higher solubility in made with the help of a COSY experiment. water relative to the indazolium salt. We also synthesized the [RuCl 4 ind 2 ] (see Figure ), is its poor water solubility, Chemistry salt 5 exhibits the best solubility in less polar solvents like Waehringerstraße 42, A-1090 Vienna, Austria chloroform.