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Synthesis of tritiated N1′-alkyl derivatives of the delta opioid receptor ligand naltrindole

✍ Scribed by John R. Lever; Suzanne M. Johnson

Publisher
John Wiley and Sons
Year
1997
Tongue
French
Weight
532 KB
Volume
39
Category
Article
ISSN
0022-2135

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Synthesis of N1′-([11C]methyl)naltrindol
Synthesis of N1′-([11C]methyl)naltrindole ([11C]MeNTI): A radioligand for positron emission tomographic studies of delta opioid receptors
✍ John R. Lever; Chris M. Kinter; Hayden T. Ravert; John L. Musachio; William B. M 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 508 KB

## Abstract A delta opioid receptor antagonist, N1′‐methylnaltrindole (MeNTI), has been labeled with carbon‐11. The precursor for radiolabeling was prepared in 71% yield by benzylation of the phenolic moiety of naltrindole. Alkylation of the indole nitrogen using [^11^C]iodomethane and aqueous tetr