✦ LIBER ✦

Synthesis of Trimethylamine-[14C]carboxyborane and Trimethylamine-[14C]carboxymethoxyborane and L1210 Leukemia Cell Uptake

✍ Scribed by S. Y. Chen; Bruce S. Burnham; Bernard F. Spielvogel; A. Sood; Steven D. Wyrick; Iris H. Hall

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 258 KB
Volume: 10
Category: Article
ISSN: 0268-2605
DOI: 10.1002/(sici)1099-0739(199604)10:3/4<279::aid-aoc470>3.0.co;2-8

No coin nor oath required. For personal study only.

✦ Synopsis

The anti-neoplastic agents trimethylaminecarboxyborane and its corresponding methyl ester have successfully been radiolabeled with carbon-14 in the carboxyl group. Using the radiolabeled agents we have shown that their L1210 leukemia cell uptake appeared to be by a passive process and binding of the agents to DNA, RNA and protein over 24 h was minimal.