Synthesis of trifunctional thioureas bearing 1,5-disubstituted triazole tether by Ru-catalyzed Huisgen cycloaddition

✍ Scribed by Kiyosei Takasu; Takumi Azuma; Yoshiji Takemoto

• Book ID: 104097632
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 494 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.03.053

✦ Synopsis

Synthesis of trifunctional thiourea catalysts tethered with a variety of functional group is described. 1,5-Triazole tether in the catalysts was constructed by ruthenium-catalyzed Huisgen cycloaddition. We demonstrate the utility of the synthetic thioureas as an asymmetric catalyst for Michal addition of nitrostyrene with cyclohexanone.