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Synthesis of Trifluoromethyl Ketones via Tandem Claisen Condensation and Retro-Claisen C–C Bond-Cleavage Reaction

✍ Scribed by Yang, Dongmei; Zhou, Yuhan; Xue, Na; Qu, Jingping


Book ID
120080814
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
482 KB
Volume
78
Category
Article
ISSN
0022-3263

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A variety of a-C-glycosides may be accessed in an entirely stereoselective fashion from 3-OH glycal esters, by way of the tandem reaction sequence of Tebbe methylenation and Claisen rearrangement. In contrast with previous studies in the corresponding b-series, careful control of conditions for Clai