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Synthesis of transferrin and albumin conjugates of the anticancer drugs chlorambucil, doxorubicin and daunorubicin

✍ Scribed by U. Beyer; B. Wohlschlegel; T. Schuütte; C. Unger; A.W. Frahm; F. Kratz


Book ID
117628740
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
98 KB
Volume
4
Category
Article
ISSN
0928-0987

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Maleimide groups were bound to the 3 '-amino position of daunorubicin through a benzamide bond or to the 13-keto position through a benzoyl hydrazone or phenylacetyl hydrazone bond. The acid labile transferrin conjugates prepared with the latter two derivatives exhibited high activity in human melan