Synthesis of trans-N,N,N-triethyl-2-[4-(2-phenylethenyl)-phenoxy]-ethanammonium iodide
✍ Scribed by Mohammed I. Al-Hassan
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 145 KB
- Volume
- 386
- Category
- Article
- ISSN
- 0022-328X
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📜 SIMILAR VOLUMES
For the title compound, C 12 H 16 N 2 O 3 , a potential anti-amnesic agent, the conformations of the molecule in the crystal structure and that of the energy-minimized free molecule do not differ significantly. Intermolecular N-HÁ Á ÁO and C-HÁ Á ÁO hydrogen bonds stabilize the crystal packing.
## Abstract A tritium labelled antihistamine, N,N‐diethyl‐2‐[4‐(phenylmethyl)phenoxy]‐ ethaneamine · HCl (DPPE, 4) was synthesized to investigate its binding characteristics to intracellular histamine receptors (H~IC~) and for further studies with specific ligands of H~IC~ to determine their potent
In the molecule of the title compound, C 23 H 20 ClFN 2 O 4 , the cyclohexene ring is not planar and has a flattened boat conformation. Intermolecular C-HÁ Á ÁO hydrogen bonds, linking the independent molecules into dimers, may be effective in the stabilization of the crystal structure.