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Synthesis of tolerogenic monomethoxypolyethylene glycol and polyvinyl alcohol conjugates of peptides

✍ Scribed by M. Zouhair Atassi; Taghi Manshouri

Book ID
112461102
Publisher
Springer
Year
1991
Tongue
English
Weight
431 KB
Volume
10
Category
Article
ISSN
1573-4943

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πŸ“œ SIMILAR VOLUMES

Tolerogenic conjugates of xenogeneic mon
Tolerogenic conjugates of xenogeneic monoclonal antibodies with monomethoxypolyethylene glycol. I. Induction of long-lasting tolerance to xenogeneic monoclonal antibodies
✍ Pradip K. Maiti; Glen M. Lang; A. H. Sehon πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 576 KB

The therapeutic effectiveness of xenogeneic monoclonal antibodies (MAbs) (xIg) or their conjugates with toxins (xIg-Tx) is undermined because of their inherent immunogenicity. This complication may be overcome by converting the antigenic xIg to tolerogenic derivatives by coupling an appropriate numb