Synthesis of Thieno[3,2-b]pyrrolenine Derivatives under the Fischer Reaction Conditions.
✍ Scribed by V. Z. Shirinian; M. M. Krayushkin; D. M. Nikalin; A. A. Shimkin
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 21 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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Scheme 2. Yb(OTf) 3 -catalyzed microwave-assisted synthesis of 3a.
## Abstract A new series of 4‐(4‐methylpiperazin‐1‐yl)thieno[2,3‐__b__][1,5]benzoxazepines **1a‐k** has been synthesized from 4‐bromo‐2‐methylthiophene **6** or ethyl 2‐amino‐4,5‐dimethyl‐3‐thiophencarboxylate **10**. Preparation of the key intermediate thieno[2,3‐__b__][1,5]benzoxazepine‐4(5__H__)
## Abstract Thieno[2,3‐__b__]indole derivatives were efficiently prepared __via__ the reaction of 1,3‐dihydro‐2__H__‐indole‐2‐thiones with __α__‐bromo‐substituted ketones or aldehydes and in the presence of Et~3~N (__Scheme 2__ and __Table__). The reaction took place under very mild conditions and