Synthesis of the X-protein of hepatitis B virus in vitro and detection of anti-X antibodies in human sera
β Scribed by Eberhard Pfaff; Jochen Salfeld; Karl Gmelin; Heinz Schaller; Lorenz Theilmann
- Book ID
- 116075354
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 922 KB
- Volume
- 158
- Category
- Article
- ISSN
- 0042-6822
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Sera of patients from China with hepatocellular carcinoma (HCC) were tested for the presence of HBc/HBe- and HBx antibodies by immunoblotting using recombinant MS2 or beta gal fusion proteins as substrate. Antibodies against HBx were detected in four out of 68 HBsAg positive and in one out of three
The X protein can act on the enhancer of hepatitis B virus in an in uitro system and elevate the transcriptional level of hepatitis B virus. However, because no relationship had been reported between X protein expression and hepatitis B virus replication in patients with chronic hepatitis B, we focu