Synthetic studies on azadirachtin (Part
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Jun Ishihara; Takehiro Fukuzaki; Akio Murai
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Article
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1999
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Elsevier Science
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French
โ 224 KB
An asymmetric synthesis of the tricyclic dihyctrofuran moiety of azadirachtin is reported. The Diels-Alder adduct, which was catalyzed by Evans' chiral Cu-bisoxazoline complex, was easily converted to the tricyclic portion via SmI 2 reductive cleavage and selective functionalization.