The partial structure 2 of the bisketal-type, tetracyclic saudin (1), an important natural product, was de novo synthesized. A key step was the Jones oxidation of the epoxide 3, which gave rise to epoxide-ring opening, followed by acetal hydrolysis, alcohol oxidation, and, finally, intramolecular ac
✦ LIBER ✦
Synthesis of the Tetracyclic Bis(acetal) Lactone Portion of Saudin
✍ Scribed by Guillermo R. Labadie; Liliana E. Luna; Manuel Gonzalez-Sierra; Raquel M. Cravero
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 131 KB
- Volume
- 2003
- Category
- Article
- ISSN
- 1434-193X
No coin nor oath required. For personal study only.
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## Abstract Esterification—condensation or addition—condensation pathways are successfully applied in the synthesis of title iminolactones (IV), bis(iminolactones) (VII) as well as bis(lactones) (XII).