Synthesis of the terminal trisaccharide unit of the lipo-oligosaccharide from Mycobacterium linda

✍ Scribed by Mukund K. Gurjar; N.Ramaiah Srinivas

• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 313 KB
• Volume: 247
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(93)84264-7

✦ Synopsis

Mycobacterium (Mj findu was first isolated from patients suffering from Crohn's diseaser. There are doubts about the implication of this bacterium in Crohn's disease because later studies* revealed the presence of mycobacteria in healthy patients. However, literature evidence 'y3 did suggest that M. Zindu has a definite role to play in the pathogenesis of Crohn's disease. The identification of the species-specific antigen therefore becomes important, particularly for serodiagnosis and for the identification of the epidiology and epidemiology of the disease. The surface glycolipid Cl), classified4 as a trehalose-containing lipo-bligosaccharide, contained the oligosaccharide: /3-D-Glcp-(1 + 3j++Rhap-(1 + 3)-wD-Glcp-(1 * lk-D-Glcp. The antigenic activity' in lipo-oligosaccharides resides in those sugars units which are placed distant from the trehalose end. This report describes the synthesis of the terminal trisaccharide (111, as a methyl glycoside, of M. lindu. The * IICT Communication No. 3098.