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Synthesis of the spirocyclic alkaloid nitramine

✍ Scribed by Lars H. Hellberg; Craig Beeson; Ratnasamy Somanathan; Centro de Graduados

No coin nor oath required. For personal study only.

✦ Synopsis

The alkaloid nitramine was prepared in a four operation process using reductive cyclization of a y-cyano ester to a spirolactam as a key step.

Recently three interesting spirocyclic alkaloids, nitramine (l), isonitramine (2) and

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