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Synthesis of the proposed core of aeruginosins 205: the new α-amino acid (2S,3aS,6R,7aS)-2-carboxy-6-chlorooctahydroindole

✍ Scribed by Nativitat Valls; Mercè Vallribera; Mercè Font-Bardı́a; Xavier Solans; Josep Bonjoch

Book ID: 104359759
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 387 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00170-8

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✦ Synopsis

The synthesis of enantiomerically pure a-amino acid (2S,3aS,6R,7aS)-2-carboxy-6-chlorooctahydroindole (L-Ccoi) is described. NMR data of L-Ccoi 3 are very different from those reported for the azabicyclic core of aeruginosins 205, indicating that the structure of these aeruginosins needs to be revised.

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