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Synthesis of the Pleuromutilin Antibiotic SB-268091: A New Practical and Efficient Synthesis of Quinuclidine-4-thiol

✍ Scribed by Choudary, Bernie; Giles, Robert G.; Jovic, Florence; Lewis, Norman; Moore, Steve; Urquhart, Michael


Book ID
118061662
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
485 KB
Volume
16
Category
Article
ISSN
1083-6160

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ChemInform Abstract: A Highly Stereosele
✍ S. HANESSIAN; M. J. ROZEMA πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 38 KB πŸ‘ 2 views

A Highly Stereoselective and Practical Total Synthesis of the Tricyclic β-Lactam Antibiotic GV104326 (4-Methoxytrinem). -The title compound (IX) is prepared in ∼ = 33% overall yield by a method which circumvents the use of enantiomerically pure (S)-2-methoxycyclohexanone. The key step is represente