Synthesis of deuterium labelled thiorida
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T. Mohammad; K. K. Midha; E. M. Hawes
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Article
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1988
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John Wiley and Sons
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French
โ 609 KB
A multistep synthetic route to (~)-10-[2-(1-methyl-2-piperidinyl)ethyl]-2-methylthio-lOH-phenothiazine (thioridazine) was developed which allowed for the incorporation of two deuterium atoms in the piperidine ring and a further two in the 1-position of the ethyl side chain. The key steps involved ru