Synthesis of the phosphodisaccharide repeat of antigenic lipophosphoglycan of Leishmania donovani parasite

✍ Scribed by Mani Upreti; Ram A. Vishwakarma

• Book ID: 104261026
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 252 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00231-2

✦ Synopsis

S~mthesis of the immunologically important and structurally unusual phosphodisaccharide repeat unit (Galpl,4lJ-Mm~l m-phosphate) of the lipophosphoglycan cell surface GPI molecule of the protozoan parasite Leishmania donovani has besa carried out using lactose as the stm-ting material. The synthesis provides a shaft and steteoselective route for the preparation of this phosphosatr, hafide in a preparative scale.